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KMID : 1123920040180030863
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 3 p.863 ~ p.867
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Apoptosis-inducing Effect of Herba Patriniae Extract in the Prostate Cancer LNCaP Cells
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Moon Hyung-Chul
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Abstract
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Herba Patriniae(HP) has been known to exert anti-inflammation and -tumoral activity in Korea. However, its molecular mechanism of action is not understood. In this study, we found that HP extract induced apoptosis in androgen-dependent prostate cancer LNCaP cells as evidenced by DNA fragmentation. Our data demonstrated that HP extract-induced apoptotic cell death was accompanied by inhibition of NF- κB activation, lowering effects of intracellular prostate specific antigen(PSA) and androgen reoeptor(AR) expression in a time dependent manner. Taken together, HP extract may inhibit the proliferation of prostate cancer LNCaP cell associated with inhibition of NF- κB activation, PSA and AR expression and that of apoptosis.
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KEYWORD
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Herba Patriniae, LNCaP cells, apoptosis, NF- κB, Prostate Specific Antigen, Androgen Receptor
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